We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligａnd binding assays to determine receptor expression levels (B_max), dissociation constants (K_d), association and dissociation rates (k_on and k_off), and inhibitor constants (K_i) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New Englａnd Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX354:

1. Meens, M., Mattheij, N., van Loenen, P., Spijkers, L., Lemkens, P., Nelissen, J., Compeer, M., Alewijnse, A. and De Mey, J. (2012), G-protein βγ subunits in vasorelaxing and anti-endothelinergic effects of calcitonin gene-related peptide. British Journal of Pharmacology, 166: 297–308.
2. Moore, E.L., Gingell, J.J., Kane, S.A., Hay, D.L., Salvatore, C.A. (2010), Mapping the CGRP receptor ligａnd binding domain: tryptophan-84 of RAMP1 is critical for agonist and antagonist binding. Biochem Biophys Res Commun, 394 (1): 141-145.