Scopolamine Methyl Chloride, [N-methyl-3H]-, 250µCi (9.25MBq)

Scopolamine Methyl Chloride, [N-methyl-3H]-, 250µCi (9.25MBq)

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2023-10-20 11:38:51
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珀金埃尔默企业管理(上海)有限公司

珀金埃尔默企业管理(上海)有限公司

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产品简介

Scopolamine methyl chloride, tritiated on the N-methyl group. Scopolamine acts as an antagonist at muscarinic acetylcholine receptors.

详细介绍

Scopolamine is a natural product antagonist of muscarinic acetylcholine receptors, and is used to treat motion sickness and nausea.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET636:

  1. Michael Salmon, Mark A. Luttmann, James J. Foley, Peter T. Buckley, Dulcie B. Schmidt, Miriam Burman, Edward F. Webb, Christopher J. DeHaas, Charles J. Kotzer, Victoria J. Barrett, Robert J. Slack, Henry M. Sarau, Michael R. Palovich, Dramane I. Lainé, Douglas W. P. Hay and William L. Rumsey, Pharmacological Characterization of GSK573719 (Umeclidinium): A Novel, Long-Acting, Inhaled Antagonist of the Muscarinic Cholinergic Receptors for Treatment of Pulmonary Diseases, Journal of Pharmacology and Experimental Therapeutics May 2013, 345 (2): 260-270.
  2. Weng-Keong Loke, Meng-Kwoon Sim, Mei-Lin Go, O-Substituted derivatives of pralidoxime: muscarinic properties and protection against soman effects in rats, European Journal of Pharmacology, 2002, 442 (3): 279-287.

规格

浓度 1.0 - 10 mCi/mL
检测方法 Radiometric
标签位置 Specifically Labeled
分子量 353.8
产品品牌名称 NEN Radiochemicals
放射性同位素 H-3
放射性核素 3H
受体类型 Acetylcholine (Muscarinic)
运输条件 干冰
特殊订购信息 This is a radioactive product - shipping address must have a license to receive radioactive materials.
治疗领域 CNS & Neurologic, Cardiovascular, Gastrointestinal
产品尺寸 250 µCi
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