羟基萘酚蓝二钠号：165660-27-5   
英文名称：Hydroxy naphthol blue disodium salt   
其他名称：羟基萘酚兰二钠盐；色酚兰二钠盐   
号：165660-27-5   
C20H12N2O11S3Na2=598.49   
级别：试剂级   
水分：≤1.0%   
重金属：≤10ppm   
性状(以下信息仅供参考)：深蓝色至蓝紫色结晶或粉末。UV absorption：λmax 650 nm   
用途：本品仅供科研，不得用于其它用途。(以下用途仅供参考)金属滴定指示剂,用于测定钙   
保存：RT 羟基萘酚蓝二钠号：165660-27-5储存条件：
避光、干燥阴凉处封闭贮存,严禁与有毒、有害物品混放、混运。本品为非危险 产品可按一般化学品运输,轻搬动轻放,防止日晒、雨淋！受热、受潮、受光后易丧失活力,保存期短,因此贮存和运输条件比较苛刻。
运输：汽车运输、EMS邮政快递，申通快递等， 款到上海3天内发货； 
售后：如您对我们的产品服务及技术指标有特殊要求，请及时通知我方。 
存储：应贮存在干燥清洁避光的环境中，严禁与有毒物质混放，以免污染（保质期为两年）。 
羟基萘酚蓝二钠号：165660-27-5主要优级纯、分级纯和化学纯3种：
（1）优级纯（GR：Guaranteed reagent），又称一级品或保证试剂，99.8%，这种试剂纯度Z高，杂质含量Z低，适合于重要精密的分析工作和科学研究工作，使用绿色瓶签。
（2）分析纯（AR），又称二级试剂，纯度很高，99.7%，略次于优级纯，适合于重要分析及一般研究工作，使用红色瓶签。
（3）化学纯（CP），又称三级试剂，≥ 99.5%，纯度与分析纯相差较大，适用于工矿、学校一般分析工作。使用蓝色（深蓝色）标签。
（4）实验试剂（LR：Laboratory reagent），又称四级试剂。
服务承诺：
工作时间内提供免费的技术咨询和指导 。我公司的销售工程师经过专业培训的，将为您提供满意的产品和真诚的服务。
白、p300、NFkB和MyoD，sirtuins可参与凋亡、细胞存活、转录和代谢等过程。以sirtuins为靶标的药物可能在治疗衰老、癌症、糖尿病和神经退行性变中有用。
英文名称  Anti-Slc26a5
中文名称  感觉神经性耳聋常染色体隐性遗传61抗体
别    名  Prestin; Deafness neurosensory autosomal recessive 61; DFNB 61; DFNB61; MGC118886; MGC118887; MGC118888; MGC118889; PRES; Prestin (motor protein); Prestin; S26A5_HUMAN; SLC26A5; Solute carrier family 26 member 5 (prestin); Solute carrier family 26 member 5.
浓    度  1mg/1ml
规 格  0.2ml/200μg
抗体来源  Rabbit 
克隆类型  polyclonal
交叉反应  Human, Mouse, Rat
产品类型  一抗   
研究领域  细胞生物 
蛋白分子量  predicted molecular weight: 81kDa
性    状  Lyophilized or Liquid
免 疫 原  KLH conjugated synthetic peptide derived from human Slc26a5 C-terminus
亚    型  IgG
纯化方法  affinity purified by Protein A
储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500
（石蜡切片需做抗原修复）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user. 
保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note  This product as supplied is intended for research use only, not for use in human, 羟基萘酚蓝二钠号：165660-27-5therapeutic or diagnostic applications.
产品介绍 SLC26A5 (Solute carrier family 26, member 5) is specifically expressed in outer hair cells (OHCs) of the cochlea and is essential in auditory processing. It acts as a motor protein that converts auditory stimuli to length changes in outer hair cells. It is a bidirectional voltage-to-force converter which uses cytoplasmic anions as extrinsic voltage sensors. The anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. This translocation triggers conformational changes in the protein that alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). It acts as an incomplete transporter since it moves anions across the membrane, but does not allow the anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the anion-binding site. Mutations in SLC26A5 have been associated with non-syndromic hearing loss.
Function : Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimay alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site (By similarity).
Subcellular Location : Cell membrane; Multi-pass membrane protein (By similarity). Note=Lateral wall of outer hair cells (By similarity).
DISEASE : Deafness, autosomal recessive, 61 (DFNB61) [MIM:613865]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Note=The disease is caused by mutations affecting the gene represented in this entry.
Similarity : Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
Contains 1 STAS domain.