固红B 号：49735-71-9  
英文名称：Fast red B salt；1-Amino-2-methoxy-4-nitrobenzene diazotated 1,5-naphthalenedisulfonate salt；2-Methoxy-4-nitrobenzenediazonium 1,5-naphthalenedisulfonate salt   
其他名称：标准重氮色盐玫瑰红；B红盐；固红B盐   
号：49735-71-9   
C7H6N3O3·C10H7O6S2=467.43   
级别：BR   
纯度：≥90.0%   
性状(以下信息仅供参考)：鲜黄色粉末。商品常是稳定的1,5-萘二磺酸盐。有刺激性   
用途：本品仅供科研，不得用于其它用途。(以下用途仅供参考)组织化学中用于重氮化偶合反应,测定磷酸酶和脂酶   
保存：RT，避光固红B 号：49735-71-9储存条件：
避光、干燥阴凉处封闭贮存,严禁与有毒、有害物品混放、混运。本品为非危险 产品可按一般化学品运输,轻搬动轻放,防止日晒、雨淋！受热、受潮、受光后易丧失活力,保存期短,因此贮存和运输条件比较苛刻。
运输：汽车运输、EMS邮政快递，申通快递等， 款到上海3天内发货； 
售后：如您对我们的产品服务及技术指标有特殊要求，请及时通知我方。 
存储：应贮存在干燥清洁避光的环境中，严禁与有毒物质混放，以免污染（保质期为两年）。 
固红B 号：49735-71-9主要优级纯、分级纯和化学纯3种：
（1）优级纯（GR：Guaranteed reagent），又称一级品或保证试剂，99.8%，这种试剂纯度Z高，杂质含量Z低，适合于重要精密的分析工作和科学研究工作，使用绿色瓶签。
（2）分析纯（AR），又称二级试剂，纯度很高，99.7%，略次于优级纯，适合于重要分析及一般研究工作，使用红色瓶签。
（3）化学纯（CP），又称三级试剂，≥ 99.5%，纯度与分析纯相差较大，适用于工矿、学校一般分析工作。使用蓝色（深蓝色）标签。
（4）实验试剂（LR：Laboratory reagent），又称四级试剂。
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储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500
（石蜡切片需做抗原修复）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user. 
保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 Shepherdin (Survivin variant; baculoviral IAP repeat-containing protein 5 isoform 3; BIRC5). Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.
Survivin is an anti-apoptotic protein, expressed in the G2/M cell cycle phase. At the onset of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptotic function and increased caspase 3 activity. Survivin is also abundantly expressed in brain tissues (astrocytes and some neurons) of adult rats following traumatic brain injury. Survivin has been found co-expressed with NeuN (mature neuronal marker) and PCNA (a cell cycle protein. Survivin might affect regulation of neural cell proliferative responses after brain injury. Survivin is also an inhibitor of apoptosis (IAP), or programmed cell death, that is selectively overexpressed in common human cancers.
Function : Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome 固红B 号：49735-71-9alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of P3 and P7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.
Subunit : Monomer or homodimer. Exists as a homodimer in the apo state and as a monomer in the CPC-bound state. The monomer protects cells against apoptosis more efficiently than the dimer. Only the dimeric form is capable of enhancing tubulin stability in cells. When phosphorylated, interacts with HBXIP; the resulting complex binds pro-P9, as well as active P9, but much less efficiently. Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB and AURKC. Interacts with JTB. Interacts with CDCA8 and INCENP; interaction is direct. Interacts with EVI5. Interacts with GTP-bound RAN in both the S and M phases of the cell cycle. Interacts with USP9X. Interacts with tubulin. Interacts with BIRC2/c-IAP1. The acetylated form at Lys-129 interacts with STAT3. The monomeric form deacetylated at Lys-129 interacts with XPO1/CRM1. The monomeric form interacts with XIAP/BIRC4. Both the dimeric and monomeric form can interact with DIABLO/SMAC. Interacts with BIRC6/bruce.
Subcellular Location : Cytoplasm. Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Midbody. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase. Localizes to kinetochores in metaphase, distributes to the midzone microtubules in anaphase and at ophase, localizes exclusively to the midbody. Colocalizes with AURKB at mitotic chromosomes. Acetylation at Lys-129 directs its localization to the nucleus by enhancing homodimerization and thereby inhibiting XPO1/CRM1-mediated nuclear export.
Tissue Specificity : Expressed only in fetal kidney and liver, and to lesser extent, lung and brain. Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas. Also expressed in various renal cell carcinoma cell lines.
Post-translational modifications : Ubiquitination is required for centrosomal targeting.
In vitro phosphorylation at Thr-117 by AURKB prevents interaction with INCENP and localization to mitotic chromosomes. Phosphorylation at Thr-48 by CK2 is critical for its mitotic and anti-apoptotic activities.
Acetylation at Lys-129 by CBP results in its homodimerization, while deacetylation promotes the formation of monomers which heterodimerize with XPO1/CRM1 which facilitates its nuclear export. The acetylated form represses STAT3 transactivation. The dynamic equilibrium between its acetylation and deacetylation at Lys-129 determines its interaction with XPO1/CRM1, its subsequent subcellular localization, and its ability to inhibit STAT3 transactivation.
Similarity : Belongs to the IAP family.
Contains 1 BIR repeat.
为Survivin家族成员，又称：细胞凋亡抑制因子4，主要用于肿瘤方面的研究。
英文名称  Anti-Syntrophin/SNTA1/Syntrophin Alpha1
中文名称  神经肌肉接头蛋白SNTA1抗体

抗体来源  Rabbit