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硫酸奎宁二水物号：6119-70-6   
英文名称：Quinine hemisulfate salt dihydrate   
其他名称：(8S,9R)-6'-甲氧基金鸡纳-9-醇硫酸盐二水物；奎宁硫酸盐二水物；奎宁硫酸酯二水物；硫酸金鸡纳盐二水物   
号：6119-70-6   
C40H48N4O4·H2O4S·2H2O=782.96   
级别：BR   
含量：≥98%   
干燥失重：≤5.0%   
PH：5.7～6.6   
性状(以下信息仅供参考)：白色至类白色粉末或针状结晶。无气味。味极苦。露光渐变褐色,约在100℃失去结晶水。饱和溶液pH6.2。极易溶于2份方与1份无水乙醇的混合液,1G溶于810ml水、32ml沸水、120ml乙醇、约10ml热乙醇。微溶于方和乙迷。有刺激性   
用途：本品仅供科研，不得用于其它用途。(以下用途仅供参考)在紫外线照射下滴定酸时作荧光指示剂,pH 3.8～6.1(天蓝～紫色),pH 9.5～10(荧光消失)。重量分析中测定钨。比色分析中测定铋。比浊法测定磷   
保存：RT，避光。保质期5年 客户根据硫酸奎宁二水物号：6119-70-6性质、化学式、分子式、结构式、比重、密度、号、沸点、熔点、水溶性、MSDS、用途、作用、规格包装、性状、注意事项、英文名、别称、纯度、级别等情况，本产品化学性质稳定，运输条件不苛刻，一般储存在阴凉，干燥，通风良好的地方，远离不相容的物质。保持容器密闭。
试剂品牌：TCI、sigma、Alfa、Avocado、Aldrich、ACROS、Fluka、ICN（MP）等
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级别：GR级别、AR级别、CP级别、L.P.级别等
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亚    型  IgG
纯化方法  affinity purified by Protein A
储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500
（石蜡切片需做抗原修复）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user. 
保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008].
Function : Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of H2AFY and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL.
Subunit : Interacts with GLI2 and GLI3. Homodimer and homooligomer. Heterodimer with SPOPL. Each dimer interacts with two CUL3 molecules. Part of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain CUL3 and homodimeric SPOP, or the heterodimer formed by SPOP and SPOPL, plus a target protein, such as H2AFY, PDX1/IPF1, BMI1, BRMS1 and DAXX.
Subcellular Location : Nucleus. Nucleus speckle.
Tissue Specificity : Widely expressed.
Similarity : Belongs to the Tdpoz family.
Contains 1 BTB (POZ) domain.
Contains 1 MATH domain.
Database links : UniProtKB/Swiss-Prot: O43791
英文名称  Anti-SP3
中文名称  转录因子SP3抗体
别    名  D130027J01Rik; DKFZp686O1631; GC binding transcription factor Sp 3; GC binding transcription factor Sp3; MGC105187; OTTMUSP00000014207; SP 3; Sp 3 transcription factor; SP3; Sp3 transcription factor; SP3_HUMAN; Specificity protein 3; SPR 2; SPR-2; SPR2; Transcription factor SP 3; Transcription factor SP3; Transcription factor Sp3.
浓    度  1mg/1ml
规 格  0.1ml/100μg  0.2ml/200μg
抗体来源  Rabbit 
克隆类型  polyclonal
交叉反应  Human, Mouse, Rat, Chicken, Cow, Rabbit
产品类型  一抗   
研究领域  细胞生物 神经生物学 细胞周期蛋白 转录调节因子 表观遗传学 
蛋白分子量  predicted molecular weight: 82kDa
性    状  Lyophilized or Liquid
免 疫 原  KLH conjugated synthetic peptide derived from human SP3
亚    型  IgG
纯化方法  affinity purified by Protein A
储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500
（石蜡切片需做抗原修复）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user.