【中文名称】：BRCA1 Polyclonal Antibody?

【英语名称】：BRCA1 Polyclonal Antibody

【产品类型】：一抗

【供应商】：Abbkine

【产品货号】：ABP50789

【产品规格】：30ul/100ul/200ul

【背景资料】：BRCA1encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein(BRCA1, DNA repair associated)combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximay 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified
蛋白别名为：BRCA1; RNF53; Breast cancer type 1 susceptibility protein; RING finger protein 53;基因ID为：672；蛋白质ID:P38398

【应用类型】：WB，IHC-p，IF，ELISA
补充：*的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: WB: 1:500-1:2000, IHC-p: 1:100-1:300, IF: 1:200-1:1000, ELISA: 1:5000. Not yet tested in other applications.

【免疫原】：合成多肽：human BRCA1 around the non-phosphorylation site of S1423.

【来源宿主】：兔

【反应性】：人，大鼠

【保存建议】：厂家*蓝冰运输.在发货后能在-20℃保存1年.为zui大限度的避免损失，请在打开管盖之前融化抗体并离心.我们建议使用前分装以避免反复冻融.
本产品为液体形式,溶解于PBS缓冲液中，含50%甘油，0.5%BSA和0.02%*.

【产品说明】：点击：BRCA1 Polyclonal Antibody??查看更详细产品说明，更多应用、储存、价格、货期等信息请Abbkine中国区域*总代理艾美捷科技有限公司。更多特色试剂盒、特色抗体以及特色试剂等产品评论，请点击查看每日生物评论。

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产品标签:BRCA1 (phospho Ser1423) Polyclonal Antibody，BRCA1 Polyclonal Antibody