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对二甲氨基亚苄基罗丹宁号：536-17-4   
英文名称：4-Dimethylaminobenzal rhodanine；p-Dimethylaminobenzal rhodanine；5-［p-(Dimethylamino)benzylidene］rhodanine；5-［(4-(Dimethylamino)phenyl)methylene］-2-thioxo-4-thiazolidinone   
其他名称：玫瑰红银试剂；对二甲氨基苯甲罗丹宁；5-［4-（二甲基氨基）苯基］亚甲基-2-硫代-4-噻唑烷酮；对二甲氨基亚苄罗丹宁；试银灵；对二甲氨基苄罗丹宁；5-(对二甲氨基亚苄基)罗丹宁；4-二甲氨基亚苄基罗丹宁；5-(4-二甲氨基亚苄基)罗丹宁   
号：536-17-4   
C12H12N2OS2=264.37   
级别：AR   
丙同溶解试验：合格   
对银灵敏度试验：合格   
灼烧残渣(以硫酸盐计)：≤0.2%   
性状(以下信息仅供参考)：深红色针状结晶。溶于强酸呈黄色，溶于丙同，微溶于沸乙醇，极微溶于方、乙迷和苯，几乎不溶于水。约260℃熔结，约280℃熔融。Z大吸收波长451nm。   
用途：本品仅供科研，不得用于其它用途。(以下用途仅供参考)有机灵敏试剂，光度测定银、金、汞、铂、钯   
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Function : NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity).
Subunit : Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked. Found in a complex with GRIN2A or GRIN2B, GRIN3A or GRIN3B and PPP2CB. Interacts with DLG4 and MPDZ (By similarity). Interacts with LRFN1 and LRFN2 (By similarity). Interacts with MYZAP.
Subcellular Location : Cell membrane. Cell junction; synapse; postsynaptic cell membrane.
Tissue Specificity : NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity (By similarity).
DISEASE : Defects in GRIN1 are the cause of mental retardation autosomal dominant type 8 (MRD8) [MIM:614254]. Mental retardation is characterized by significantly below average general inlectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.
Similarity : Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.
Database links : UniProtKB/Swiss-Prot: Q05586.1
英文名称  Anti-NMDA epsilon 2
中文名称  *受体NMDAζ2抗体
别    名  N-Methyl-d-Asprtate receptor epsilon 2; Glutamate Receptor Ionotropic N Methyl D Aspartate epsilon-2; N Methly D Aspartate Receptor Channel Subunit Epsilon 2; 
浓    度  1mg/1ml
规 格  0.2ml/200μg
抗体来源  Rabbit 
克隆类型  polyclonal
交叉反应  Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep 
产品类型  一抗   
研究领域  细胞生物 神经生物学 细胞膜受体 
蛋白分子量  predicted molecular weight: 164kDa
性    状  Lyophilized or Liquid
免 疫 原  KLH conjugated synthetic peptide derived from human NMDA epsilon 2
亚    型  IgG
对二甲氨基亚苄基罗丹宁号：536-17-4纯化方法  affinity purified by Protein A
储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  Flow-Cyt=1:100-500  ICC=1:100-500  IF=1:100-500
（石蜡切片需做抗原修复）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user. 
保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Lonotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to -7. The kainate/AMPA receptors are primarily responsible for fast excitatory neurotransmission by glutamate, whereas the NMDA receptors exhibit slow kinesis of Ca2+ ions and a high permeability for Ca2+ ions.
Function : NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).
Subunit : Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and